Nucleotides are the building blocks of DNA and RNA. Each nucleotide consists of a nucleobase, a phosphate group, and a sugar. Each nucleotide in DNA has one of four nucleobases: adenosine ...

Thanks to a serendipitous discovery and a lot of painstaking work, scientists can now build biohybrid molecules that combine ...

Most DNA molecules consist of two polymers (double-stranded) of four nucleotides that each consist of a nucleobase, the carbohydrate deoxyribose and a phosphate group, where the carbohydrate and ...

First, it doesn’t require any of the nucleobase modifications that conventional mRNA vaccines depend on for improved stability. Second, it simply uses “naked” RNA injected directly without a ...

Scientists have discovered a method to create biohybrid molecules combining DNA and proteins using bacterial enzymes. This ...

Furthermore, the study of nucleobase sequences across different species can provide valuable insights into evolutionary relationships and the history of life on Earth. Comparative genomics, which ...

Identification of potent COVID-19 main protease inhibitors by loading of favipiravir on Mg12O12 and Zn12O12 nanoclusters: an in silico strategy for COVID-19 treatment.

However, its role as a nucleobase in RNA was not established until the 1940s, when the structure of DNA and RNA was elucidated. The discovery of uracil and its pairing with adenine in RNA was a ...

Metabolic rewiring is essential for osteoclast differentiation and bone resorption. This study shows that glutaminolysis ...

Mutations of amino acids that contact the guanine nucleobase efface kinase activity in vitro and Trl1 function in vivo.

Notably, the deoxy guanosine riboswitch achieves its specificity by modifying key interactions involving the nucleobase and through rearrangement of the ligand-binding pocket, so as to accommodate the ...