Thanks to a serendipitous discovery and a lot of painstaking work, scientists can now build biohybrid molecules that combine ...

Furthermore, the study of nucleobase sequences across different species can provide valuable insights into evolutionary relationships and the history of life on Earth. Comparative genomics, which ...

First, it doesn’t require any of the nucleobase modifications that conventional mRNA vaccines depend on for improved stability. Second, it simply uses “naked” RNA injected directly without a ...

However, its role as a nucleobase in RNA was not established until the 1940s, when the structure of DNA and RNA was elucidated. The discovery of uracil and its pairing with adenine in RNA was a ...

Scientists have discovered a method to create biohybrid molecules combining DNA and proteins using bacterial enzymes. This ...

Most DNA molecules consist of two polymers (double-stranded) of four nucleotides that each consist of a nucleobase, the carbohydrate deoxyribose and a phosphate group, where the carbohydrate and ...

1) Optochemical control of oligonucleotide function. We are developing tools that enable light-regulation of DNA and RNA function in cells and animals. Our approach is based on a fundamental concept: ...

Mutations of amino acids that contact the guanine nucleobase efface kinase activity in vitro and Trl1 function in vivo.

NuFold is a state-of-the-art method designed for predicting 3D RNA structures, leveraging deep learning for high accuracy and reliability. This tool is particularly useful for biologists and ...

The patent also describes the intended outcomes of the gene editing, such as inducing nucleobase alterations that could lead to frame shifts, premature stop codons, or aberrant transcripts in the ...

This oligonucleotide features a nucleobase sequence that includes at least 15 contiguous nucleobases from a specified sequence (SEQ ID NO: 2021). The claims detail various modifications that can be ...