Objectives Cardiovascular disease (CVD) is a leading cause of death in SLE. Coronary artery calcium (CAC) scores predict CVD events, independent of traditional risk factors. Patients with SLE aged >45 ...

Hemophagocytic lymphohistiocytosis (HLH) is a well-recognised complication of systemic lupus erythematosus (SLE). In one small case series, HLH was noted in approximately 5% of patients with lupus. 1 ...

Systemic lupus erythematosus (SLE) is associated with increased expression of genes regulated by Type I interferon (IFN) in 50–70% of patients. 1 Previous studies, including our own, have demonstrated ...

As a consequence of increased survival over the last decades, patients with systemic lupus erythematosus (SLE) and their partners have an increased wish for pregnancy. However, pregnancy in SLE is ...

Case 1: A 28-year-old Mestizo female with diffuse alveolar hemorrhage A 28-year-old Mestizo female was diagnosed with systemic lupus erythematosus (SLE) a year ago, based on fever, polyarthralgia/its, ...

A meta-analysis of the four relevant randomized clinical trials evaluating direct oral anticoagulants (DOACs) versus warfarin in thrombotic antiphospholipid syndrome (APS) showed a significant ...

Case 2: An Afro-Caribbean female with atypical chest pain An Afro-Caribbean female presented with neuropsychiatric lupus at the age of 28 years and was treated with intravenous cyclophosphamide. Her ...

Immune dysregulation in systemic lupus erythematosus (SLE) results in the autoimmune manifestations of SLE, but also leads to an impaired immune response to pathogens and vulnerability to infections ...

Despite advancements in lupus management over the past two decades, infection remains a significant cause of morbidity and mortality among patients with systemic lupus erythematosus (SLE). 1 2 Various ...

Objectives In childhood-onset SLE (cSLE), patients have an increased risk of premature atherosclerosis. The pathophysiological mechanisms for this premature atherosclerosis are not yet completely ...

Systemic lupus erythematosus (SLE) is a heterogeneous disease characterised by abnormalities in cellular and humoral immunity. The clinical complexity of SLE patients also comprise dysregulation of ...

With its first description published in 1976 the bimodal mortality pattern in systemic lupus erythematosus (SLE) described early mortality as usually being due to lupus disease itself or infection, ...