Imbalances in pyrimidine biosynthesis can lead to various disorders, such as orotic aciduria and pyrimidine nucleoside phosphorylase deficiency. Some pyrimidine analogs, such as azidothymidine (AZT) ...

It has a plasma half-life of approximately 12 h, is cleared by both renal and hepatic routes, and undergoes limited CYP metabolism, resulting in low potential drug–drug interactions. When given ...

have discovered how cellular metabolism fluctuates in response to changes in levels of pyrimidines, metabolites used by cells to make DNA and RNA, according to a study published in Science.

The purine structure consists of a pyrimidine ring (positions 1 to 6 ... GTP is also a substrate for the synthesis of RNA during transcription. Purine metabolism involves the synthesis and breakdown ...

Metabolic rewiring is essential for osteoclast differentiation and bone resorption. This study shows that glutaminolysis ...

Panax notoginseng, a perennial herb central to traditional Chinese medicine, is celebrated for its health benefits, such as promoting blood circulation and reducing inflammation. Its key components, ...

In addition to its effects on purine metabolism, AP, via its metabolite, oxipurinol ribonucleotide, inhibits pyrimidine biosynthesis (PB) at the level of orotidine mono-phosphate decarboxylase.

Generating that energy from calories happens via a process called metabolism. In this article, we'll explore how metabolism ...

The UAB Division of Endocrinology, Diabetes, and Metabolism is an integral part of one of the nation's largest health systems. Nationally known for our compassionate care, cutting-edge research, and ...

I am a scientist and researcher, and my lab focuses on exploring the complex relationship between metabolism, stress and aging. Ultimately, we hope this work will provide strategies to promote ...

Market research firm Future Market Insights projects a total of US$ 150.3 million to be generated by the serine amino acid ...

Understanding how cells process nutrients and produce energy—collectively known as metabolism—is essential in biology. Modern biology generates large datasets on various cellular activities ...